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What governs how fast we age? Why do some biological processes stop working earlier than others? And what is happening at the molecular and cellular level as some organisms age while others continue to thrive?

Although seemingly philosophical in nature, these questions address one of the major mysteries of biology, the process of aging. With recent developments in genetics, molecular biology, and genomics, we now have the possibility of addressing these questions at the molecular level. Because our ultimate goal is not simply to extend lifespan, but to improve overall health, we must identify the genes associated with biological functions that we typically associate with quality of life. The goal of our laboratory's work is to understand the molecular mechanisms governing longevity and maintenance of the biological processes that exhibit age-related decline.

Recent Publications

Contact information

Carl Icahn Lab 148
Princeton University
Princeton NJ, 08540

Lab phone: 609-258–9505

Coleen Murphy

  • Professor of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics
  • Director of the Paul F. Glenn Laboratories for Aging Research at Princeton University
Phone: 609-258–9396

Dawn Capizzi

  • Faculty Assistant
Phone: 609-258–1617