What governs how fast we age? Why do some biological processes stop working earlier than others? And what is happening at the molecular and cellular level as some organisms age while others continue to thrive?
Although seemingly philosophical in nature, these questions address one of the major mysteries of biology, the process of aging. With recent developments in genetics, molecular biology, and genomics, we now have the possibility of addressing these questions at the molecular level. Because our ultimate goal is not simply to extend lifespan, but to improve overall health, we must identify the genes associated with biological functions that we typically associate with quality of life. The goal of our laboratory's work is to understand the molecular mechanisms governing longevity and maintenance of the biological processes that exhibit age-related decline.
Recent Publications
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1. Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop
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2. Protocol for transgenerational learned pathogen avoidance behavior assays in Caenorhabditis elegans
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3. High-throughput behavioral screen in C. elegans reveals novel Parkinson’s disease drug candidates
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4. Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypotic stress?
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1. “Horizontal and vertical transmission of transgenerational memories via the Cer1 transposon
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2. PQM-1 controls hypoxic survival via regulation of lipid metabolism
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3. Sex and Death
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4. Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria
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5. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance
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6. Oleic acid protects Caenorhabditis mothers from mating-induced death