What governs how fast we age? Why do some biological processes stop working earlier than others? And what is happening at the molecular and cellular level as some organisms age while others continue to thrive?
Although seemingly philosophical in nature, these questions address one of the major mysteries of biology, the process of aging. With recent developments in genetics, molecular biology, and genomics, we now have the possibility of addressing these questions at the molecular level. Because our ultimate goal is not simply to extend lifespan, but to improve overall health, we must identify the genes associated with biological functions that we typically associate with quality of life. The goal of our laboratory's work is to understand the molecular mechanisms governing longevity and maintenance of the biological processes that exhibit age-related decline.
Recent Publications
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High-throughput behavioral screen in C. elegans reveals novel Parkinson’s disease drug candidates
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C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance
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C. elegans “read” bacterial non-coding RNA to learn pathogenic avoidance
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CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling
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CREB non-autonomously regulates Reproductive Aging through Hedgehog/Patched Signalling
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High-throughput behavioral screen in C. elegans reveals novel Parkinson’s disease drug candidates
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“Horizontal and vertical transmission of transgenerational memories via the Cer1 transposon
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Metabolic defects cause hyperactive mitochondria and Parkinson’s disease-like traits
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Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria
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Oleic acid protects Caenorhabditis mothers from mating-induced death