@article{131,
  keywords = {C.~elegans, CP: Neuroscience, Aging, cognition, Hippocampus, Memory, Neurons, rejuvenation},
  author = {Morgan Stevenson and Gregor Bieri and Rachel Kaletsky and Jonathan St Ange and L Remesal and Karishma Pratt and Shiyi Zhou and Yifei Weng and Coleen Murphy and Saul Villeda},
  title = {Neuronal activation of G EGL-30/GNAQ late in life rejuvenates cognition across species.},
  abstract = {<p>Loss of cognitive function with age is devastating. EGL-30/GNAQ and G signaling pathways are highly conserved between C.\&nbsp;elegans and mammals, and murine Gnaq is enriched in hippocampal neurons and declines with age. We found that activation of EGL-30 in aged worms triples memory span, and GNAQ gain of function significantly improved memory in aged mice: GNAQ(gf) in hippocampal neurons of 24-month-old mice (equivalent to 70- to 80-year-old humans) rescued age-related impairments in well-being and memory. Single-nucleus RNA sequencing revealed increased expression of genes regulating synaptic function, axon guidance, and memory in GNAQ-treated mice, and worm orthologs of these genes were required for long-term memory extension in worms. These experiments demonstrate that C.\&nbsp;elegans is a powerful model to identify mammalian regulators of memory, leading to the identification of a pathway that improves memory in extremely old mice. To our knowledge, this is the oldest age at which an intervention has improved age-related cognitive decline.</p>
},
  year = {2023},
  journal = {Cell reports},
  volume = {42},
  pages = {113151},
  month = {09/2023},
  issn = {2211-1247},
  doi = {10.1016/j.celrep.2023.113151},
  language = {eng},
}