@article{16,
  keywords = {Animals, Caenorhabditis elegans, Insulin, Longevity, Insulin-Like Growth Factor I, Signal Transduction, Transforming Growth Factor beta},
  author = {Wendy Shaw and Shijing Luo and Jessica Landis and Jasmine Ashraf and Coleen Murphy},
  title = {The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.},
  abstract = { <p><b>BACKGROUND: </b>Previous genetic evidence suggested that the C. elegans TGF-beta Dauer pathway is responsible solely for the regulation of dauer formation, with no role in longevity regulation, whereas the insulin/IGF-1 signaling (IIS) pathway regulates both dauer formation and longevity.</p>

<p><b>RESULTS: </b>We have uncovered a significant longevity-regulating activity by the TGF-beta Dauer pathway that is masked by an egg-laying (Egl) phenotype; mutants in the pathway display up to 2-fold increases in life span. The expression profiles of adult TGF-beta mutants overlap significantly with IIS pathway profiles: Adult TGF-beta mutants regulate the transcription of many DAF-16-regulated genes, including genes that regulate life span, the two pathways share enriched Gene Ontology categories, and a motif previously associated with DAF-16-regulated transcription (the DAE, or DAF-16-associated element) is overrepresented in the promoters of TGF-beta regulated genes. The TGF-beta Dauer pathway{\textquoteright}s regulation of longevity appears to be mediated at least in part through insulin interactions with the IIS pathway and the regulation of DAF-16 localization.</p>

<p><b>CONCLUSIONS: </b>Together, our results suggest there are TGF-beta-specific downstream targets and functions, but that the TGF-beta and IIS pathways might be more tightly linked in the regulation of longevity than has been previously appreciated.</p>
 },
  year = {2007},
  journal = {Curr Biol},
  volume = {17},
  pages = {1635-45},
  month = {2007 Oct 09},
  issn = {0960-9822},
  doi = {10.1016/j.cub.2007.08.058},
  language = {eng},
}