@article{21,
  keywords = {Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Forkhead Transcription Factors, Insulin, Longevity, Receptor, IGF Type 1, Transcription Factors, Feedback, Physiological, Signal Transduction, DNA-Binding Proteins, Down-Regulation, Aquaporin 1, Gene Knockout Techniques, Glucose, Glycerol, Heat Shock Transcription Factors},
  author = {Seung-Jae Lee and Coleen Murphy and Cynthia Kenyon},
  title = {Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.},
  abstract = { <p>Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on life span itself. We found that adding a small amount of glucose to the medium (2\%) shortened the life span of C. elegans by inhibiting the activities of life span-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the downregulation of an aquaporin glycerol channel, aqp-1. We show that changes in glycerol metabolism are likely to underlie the life span-shortening effect of glucose and that aqp-1 may act cell nonautonomously as a feedback regulator in the insulin/IGF-1-signaling pathway. Insulin downregulates similar glycerol channels in mammals, suggesting that this glucose-responsive pathway might be conserved evolutionarily. Together, these findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms.</p>
 },
  year = {2009},
  journal = {Cell Metab},
  volume = {10},
  pages = {379-91},
  month = {2009 Nov},
  issn = {1932-7420},
  doi = {10.1016/j.cmet.2009.10.003},
  language = {eng},
}