@article{23, keywords = {Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Forkhead Transcription Factors, Transcription Factors, Signal Transduction, Organ Specificity}, author = {Jessica Landis and Coleen Murphy}, title = {Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.}, abstract = {

In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.

}, year = {2010}, journal = {Dev Dyn}, volume = {239}, pages = {1405-12}, month = {2010 May}, issn = {1097-0177}, doi = {10.1002/dvdy.22244}, language = {eng}, }