Salman Sohrabi

Postdoctoral Researcher
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My research interests lie in applying the principles of fluid mechanics and nano-engineering to biology and medicine. During my master’s and Ph.D., I used microfluidics to study drug delivery, blood cell damage, cell separation and isolation, bio-printing, circulating tumor cell capture, and urine concentrating mechanism in the kidney. Currently, I am continuing my work in highly interdisciplinary topics at the interface of biology and engineering by designing high-throughput devices and methods for “quality of life” assays regularly being carried out in the Murphy lab.

Using my expertise in coding, microfluidic chip fabrication, fluid mechanics, and device design and in close collaboration with my neuroscientist lab mates, we have developed a high-throughput behavioral analysis assay for the study of Parkinson’s-related phenotypes in C. elegans. Our newly automated high-throughput platform has reliable precision, performance, and efficiency, and can record, process, and analyze data 30x faster than the equivalent manual assay.

As the only engineer in this molecular biology lab, I am also developing a fully-automated platform capable of performing short- and long-term associative memory (STAM and LTAM) assays with minimum user intervention. This platform can expedite research related to memory, such as Alzheimer’s disease mechanisms and potential treatment targets using C. elegans. I am also developing high-throughput devices to automate laborious manual life span and reproductive assays. By developing this automated device, we are providing better and faster tools to study the genetic and molecular mechanisms underlying aging and reproductive aging.