Conserved regulators of cognitive aging: From worms to humans.

Publication Year
2017

Type

Journal Article
Abstract

Cognitive decline is a major deficit that arises with age in humans. While some research on the underlying causes of these problems can be done in humans, harnessing the strengths of small model systems, particularly those with well-studied longevity mutants, such as the nematode C. elegans, will accelerate progress. Here we review the approaches being used to study cognitive decline in model organisms and show how simple model systems allow the rapid discovery of conserved molecular mechanisms, which will eventually enable the development of therapeutics to slow cognitive aging.

Journal
Behav Brain Res
Volume
322
Issue
Pt B
Pages
299-310
Date Published
2017 03 30
ISSN Number
1872-7549
Alternate Journal
Behav. Brain Res.
PMID
27329151