Coleen Murphy

First name
Coleen
Last name
Murphy
  • Shaw W, Luo S, Landis J, Ashraf J, Murphy C. 2007. The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol. 17(19):1635-45. doi:10.1016/j.cub.2007.08.058.
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  • Caudy A, Guan Y, Jia Y, Hansen C, DeSevo C, Hayes A, Agee J, Alvarez-Dominguez J, Arellano H, Barrett D, et al. 2013. A new system for comparative functional genomics of Saccharomyces yeasts. Genetics. 195(1):275-87. doi:10.1534/genetics.113.152918.
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  • Crocker A, Guan X-J, Murphy C, Murthy M. 2016. Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression. Cell Rep. 15(7):1580-1596. doi:10.1016/j.celrep.2016.04.046.
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  • Murphy C, Lee S-J, Kenyon C. 2007. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A. 104(48):19046-50. doi:10.1073/pnas.0709613104.
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  • Murphy C, Hu P. 2013. Insulin/insulin-like growth factor signaling in C. elegans. WormBook.:1-43. doi:10.1895/wormbook.1.164.1.
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  • Shi C, Murphy C. 2016. Feeding the germline. Genes Dev. 30(3):249-50. doi:10.1101/gad.276980.115.
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  • Chikina M, Huttenhower C, Murphy C, Troyanskaya O. 2009. Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans. PLoS Comput Biol. 5(6):e1000417. doi:10.1371/journal.pcbi.1000417.
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  • Tepper R, Murphy C, Bussemaker H. 2014. DAF-16 and PQM-1: partners in longevity. Aging (Albany NY). 6(1):5-6. doi:10.18632/aging.100628.
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  • Arey R, Murphy C. 2017. Conserved regulators of cognitive aging: From worms to humans. Behav Brain Res. 322(Pt B):299-310. doi:10.1016/j.bbr.2016.06.035.
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  • Oliveira R, Abate J, Dilks K, Landis J, Ashraf J, Murphy C, Blackwell K. 2009. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell. 8(5):524-41. doi:10.1111/j.1474-9726.2009.00501.x.
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  • Shi C, Murphy C. 2014. Mating induces shrinking and death in Caenorhabditis mothers. Science. 343(6170):536-40. doi:10.1126/science.1242958.
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  • Son H, Seo M, Ham S, Hwang W, Lee D, An S, Artan M, Seo K, Kaletsky R, Arey R, et al. 2017. RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans. Nat Commun. 8:14749. doi:10.1038/ncomms14749.
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  • Lee S-J, Murphy C, Kenyon C. 2009. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10(5):379-91. doi:10.1016/j.cmet.2009.10.003.
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  • de Abreu D, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes W, Nash Z, López-Moyado I, Vaggi F, et al. 2014. An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genet. 10(3):e1004225. doi:10.1371/journal.pgen.1004225.
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  • Shi C, Runnels A, Murphy C, Dillin A. 2017. Mating and male pheromone kill \textitCaenorhabditis males through distinct mechanisms. eLife. 6:e23493. doi:10.7554/eLife.23493. https://doi.org/10.7554/eLife.23493.
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  • Heimbucher T, Murphy C. 2019. Investigating Mechanisms that Control Ubiquitin-Mediated DAF-16/FOXO Protein Turnover. Methods Mol Biol. 1890:41-49. doi:10.1007/978-1-4939-8900-3_4.
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  • Luo S, Shaw W, Ashraf J, Murphy C. 2009. TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. PLoS Genet. 5(12):e1000789. doi:10.1371/journal.pgen.1000789.
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  • Stein G, Murphy C. 2014. C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm. Neurobiol Learn Mem. 115:86-94. doi:10.1016/j.nlm.2014.07.011.
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  • Shi C, Runnels A, Murphy C. 2016. Mating-induced Male Death and Pheromone Toxin-regulated Androstasis. bioRxiv.. doi:10.1101/034181. https://www.biorxiv.org/content/early/2016/11/22/034181.
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  • Yao V, Kaletsky R, Keyes W, Mor D, Wong A, Sohrabi S, Murphy C, Troyanskaya O. 2018. An integrative tissue-network approach to identify and test human disease genes. Nat Biotechnol.. doi:10.1038/nbt.4246.
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  • Landis J, Murphy C. 2010. Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev Dyn. 239(5):1405-12. doi:10.1002/dvdy.22244.
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  • Li S, Stone H, Murphy C. 2015. A microfluidic device and automatic counting system for the study of C. elegans reproductive aging. Lab Chip. 15(2):524-31. doi:10.1039/c4lc01028k.
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  • Maliha G, Murphy C. 2016. A simple offspring-to-mother size ratio predicts post-reproductive lifespan. bioRxiv.. doi:10.1101/048835. https://www.biorxiv.org/content/early/2016/04/15/048835.
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  • Tabuchi T, Rechtsteiner A, Jeffers T, Egelhofer T, Murphy C, Strome S. 2018. Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis. Nat Commun. 9(1):4310. doi:10.1038/s41467-018-06236-8.
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  • Kauffman A, Ashraf J, Corces-Zimmerman R, Landis J, Murphy C. 2010. Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biol. 8(5):e1000372. doi:10.1371/journal.pbio.1000372.
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  • Lakhina V, Arey R, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, Murphy C. 2015. Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs. Neuron. 85(2):330-45. doi:10.1016/j.neuron.2014.12.029.
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  • Shi C, Booth L, Murphy C, Kaeberlein M, Wittkopp P, Sutphin G. 2019. Insulin-like peptides and the mTOR-TFEB pathway protect \textitCaenorhabditis elegans hermaphrodites from mating-induced death. eLife. 8:e46413. doi:10.7554/eLife.46413. https://doi.org/10.7554/eLife.46413.
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  • Kaletsky R, Yao V, Williams A, Runnels A, Tadych A, Zhou S, Troyanskaya O, Murphy C. 2018. Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression. PLoS Genet. 14(8):e1007559. doi:10.1371/journal.pgen.1007559.
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  • Kaletsky R, Murphy C. 2010. The role of insulin/IGF-like signaling in C. elegans longevity and aging. Dis Model Mech. 3(7-8):415-9. doi:10.1242/dmm.001040.
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  • Lakhina V, Murphy C. 2015. For longevity, perception is everything. Cell. 160(5):807-809. doi:10.1016/j.cell.2015.02.027.
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  • Murphy C. 2019. Being Open to the Unexpected. Mol Biol Cell.
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  • Arey R, Stein G, Kaletsky R, Kauffman A, Murphy C. 2018. Activation of G Signaling Enhances Memory Consolidation and Slows Cognitive Decline. Neuron. 98(3):562-574.e5. doi:10.1016/j.neuron.2018.03.039.
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  • Luo S, Kleemann G, Ashraf J, Shaw W, Murphy C. 2010. TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. Cell. 143(2):299-312. doi:10.1016/j.cell.2010.09.013.
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  • Ewald C, Landis J, Abate J, Murphy C, Blackwell K. 2015. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 519(7541):97-101. doi:10.1038/nature14021.
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  • Templeman NM, Cota V, Keyes W, Kaletsky R, Murphy C. 2020. 7. CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling. Dev Cell. https://pubmed.ncbi.nlm.nih.gov/32544391/.
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  • Templeman N, Luo S, Kaletsky R, Shi C, Ashraf J, Keyes W, Murphy C. 2018. Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. Curr Biol. 28(5):753-760.e4. doi:10.1016/j.cub.2018.01.052.
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  • Murphy C. 2010. Aging: miRacles of longevity?. Curr Biol. 20(24):R1076-8. doi:10.1016/j.cub.2010.11.018.
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  • Hahm J-H, Kim S, DiLoreto R, Shi C, Lee S-J, Murphy C, Nam H. 2015. C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nat Commun. 6:8919. doi:10.1038/ncomms9919.
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  • Hsu A-L, Murphy C, Kenyon C. 2003. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 300(5622):1142-5. doi:10.1126/science.1083701.
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  • Luo S, Murphy C. 2011. Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms. Genesis. 49(2):53-65. doi:10.1002/dvg.20694.
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  • Lakhina V, Murphy C. 2015. Genome Sequencing Fishes out Longevity Genes. Cell. 163(6):1312-3. doi:10.1016/j.cell.2015.11.040.
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  • Murphy C, McCarroll S, Bargmann C, Fraser A, Kamath R, Ahringer J, Li H, Kenyon C. 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 424(6946):277-83. doi:10.1038/nature01789.
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  • Rizki G, Iwata T, Li J, Riedel C, Picard C, Jan M, Murphy C, Lee S. 2011. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet. 7(9):e1002235. doi:10.1371/journal.pgen.1002235.
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  • Wang J, Kaletsky R, Silva M, Williams A, Haas L, Androwski R, Landis J, Patrick C, Rashid A, Santiago-Martinez D, et al. 2015. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Curr Biol. 25(24):3232-8. doi:10.1016/j.cub.2015.10.057.
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  • McCarroll S, Murphy C, Zou S, Pletcher S, Chin C-S, Jan Y, Kenyon C, Bargmann C, Li H. 2004. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet. 36(2):197-204. doi:10.1038/ng1291.
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  • Liu G, Rogers J, Murphy C, Rongo C. 2011. EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. EMBO J. 30(15):2990-3003. doi:10.1038/emboj.2011.195.
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  • Kaletsky R, Lakhina V, Arey R, Williams A, Landis J, Ashraf J, Murphy C. 2016. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature. 529(7584):92-6. doi:10.1038/nature16483.
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  • Kenyon C, Murphy C. 2006. Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nat Genet. 38(4):397-8; author reply 398. doi:10.1038/ng0406-397.
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  • Stein G, Murphy C. 2012. The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans. Front Genet. 3:259. doi:10.3389/fgene.2012.00259.
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  • DiLoreto R, Murphy C. 2015. The cell biology of aging. Mol Biol Cell. 26(25):4524-31. doi:10.1091/mbc.E14-06-1084.
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