Feeding the germline.

TitleFeeding the germline.
Publication TypeJournal Article
Year of Publication2016
AuthorsShi C, Murphy CT
JournalGenes Dev
Volume30
Issue3
Pagination249-50
Date Published2016 Feb 01
ISSN1549-5477
KeywordsAnimals, Caenorhabditis elegans, Glucagon-Like Peptide 1, Nucleotides, Receptors, Notch, Signal Transduction
Abstract

Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307-320) have used Caernohabditis elegans to identify a GLP-1-dependent checkpoint that senses food (bacterially)-supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.

DOI10.1101/gad.276980.115
Alternate JournalGenes Dev.
Full Text
PubMed ID26833726
PubMed Central IDPMC4743054