Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.

TitleIntegration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.
Publication TypeJournal Article
Year of Publication2010
AuthorsLandis JN, Murphy CT
JournalDev Dyn
Volume239
Issue5
Pagination1405-12
Date Published2010 May
ISSN1097-0177
KeywordsAnimals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Forkhead Transcription Factors, Organ Specificity, Signal Transduction, Transcription Factors
Abstract

In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.

DOI10.1002/dvdy.22244
Alternate JournalDev. Dyn.
PubMed ID20140911
PubMed Central IDPMC3811053
Grant ListDP2 OD004402 / OD / NIH HHS / United States
R01 AG034446 / AG / NIA NIH HHS / United States