Mating induces shrinking and death in Caenorhabditis mothers.

TitleMating induces shrinking and death in Caenorhabditis mothers.
Publication TypeJournal Article
Year of Publication2014
AuthorsShi C, Murphy CT
JournalScience
Volume343
Issue6170
Pagination536-40
Date Published2014 Jan 31
ISSN1095-9203
KeywordsAnimals, Biological Evolution, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cytochrome P-450 Enzyme System, Female, Floxuridine, Longevity, Male, Osmotic Pressure, Receptors, Cytoplasmic and Nuclear, Reproduction, Sexual Behavior, Animal, Spermatozoa
Abstract

Interactions between the germ line and the soma help optimize reproductive success. We discovered a phenomenon linking reproductive status to longevity: In both hermaphroditic and gonochoristic Caenorhabditis, mating leads to female shrinking and death, compressing postreproductive life span. Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress susceptibility, and subsequent life-span decrease, whereas seminal fluid induces DAF-16-dependent life-span decrease and fat loss. Our study provides insight into the communication between males and the female germ line and soma to regulate reproduction and longevity, revealing a high-reproduction, low-life-span state induced by mating. Postmating somatic collapse may be an example of the sexually antagonistic influence that males in many species exert on female behavior to maximize their own reproductive success.

DOI10.1126/science.1242958
Alternate JournalScience
Full Text
PubMed ID24356112
Grant ListDP2OD004402 / OD / NIH HHS / United States