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100 Publications

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Sohrabi, S, DE Mor, R Kaletsky, W Keyes, and CT Murphy. n.d. “9c. High-Throughput Behavioral Screen in C. Elegans Reveals Novel Parkinson’s Disease Drug Candidates”. Comm Biology.

1998

Murphy, C, and J Spudich. 1998. “Dictyostelium Myosin 25-50K Loop Substitutions Specifically Affect ADP Release Rates.”. Biochemistry 37 (19): 6738-44. doi:10.1021/bi972903j.

1999

Murphy, C, and J Spudich. 1999. “The Sequence of the Myosin 50-20K Loop Affects Myosin’s Affinity for Actin Throughout the Actin-Myosin ATPase Cycle and Its Maximum ATPase Activity.”. Biochemistry 38 (12): 3785-92. doi:10.1021/bi9826815.

2000

Murphy, C, and J Spudich. (2000) 2000. “Variable Surface Loops and Myosin Activity: Accessories to a Motor.”. J Muscle Res Cell Motil 21 (2): 139-51.

2001

Murphy, C, R Rock, and J Spudich. (2001) 2001. “A Myosin II Mutation Uncouples ATPase Activity from Motility and Shortens Step Size.”. Nat Cell Biol 3 (3): 311-5. doi:10.1038/35060110.

2003

Hsu, Ao-Lin, Coleen Murphy, and Cynthia Kenyon. 2003. “Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor.”. Science 300 (5622): 1142-5. doi:10.1126/science.1083701.
Murphy, Coleen, Steven McCarroll, Cornelia Bargmann, Andrew Fraser, Ravi Kamath, Julie Ahringer, Hao Li, and Cynthia Kenyon. 2003. “Genes That Act Downstream of DAF-16 to Influence the Lifespan of Caenorhabditis Elegans.”. Nature 424 (6946): 277-83. doi:10.1038/nature01789.

2004

McCarroll, Steven, Coleen Murphy, Sige Zou, Scott Pletcher, Chen-Shan Chin, Yuh Jan, Cynthia Kenyon, Cornelia Bargmann, and Hao Li. (2004) 2004. “Comparing Genomic Expression Patterns across Species Identifies Shared Transcriptional Profile in Aging.”. Nat Genet 36 (2): 197-204. doi:10.1038/ng1291.

2006

Kenyon, Cynthia, and Coleen Murphy. (2006) 2006. “Enrichment of Regulatory Motifs Upstream of Predicted DAF-16 Targets.”. Nat Genet 38 (4): 397-8; author reply 398. doi:10.1038/ng0406-397.
Murphy, Coleen. (2006) 2006. “The Search for DAF-16 FOXO Transcriptional Targets: Approaches and Discoveries.”. Exp Gerontol 41 (10): 910-21. doi:10.1016/j.exger.2006.06.040.
Murphy, Coleen. 2006. “Using Whole-Genome Transcriptional Analyses to Identify Molecular Mechanisms of Aging”. Drug Discovery Today: Disease Mechanisms 3: 41-46. doi:https://doi.org/10.1016/j.ddmec.2006.02.012.

2007

Shaw, Wendy, Shijing Luo, Jessica Landis, Jasmine Ashraf, and Coleen Murphy. 2007. “The C. Elegans TGF-Beta Dauer Pathway Regulates Longevity via Insulin Signaling.”. Curr Biol 17 (19): 1635-45. doi:10.1016/j.cub.2007.08.058.
Murphy, Coleen, Seung-Jae Lee, and Cynthia Kenyon. 2007. “Tissue Entrainment by Feedback Regulation of Insulin Gene Expression in the Endoderm of Caenorhabditis Elegans.”. Proc Natl Acad Sci U S A 104 (48): 19046-50. doi:10.1073/pnas.0709613104.

2009

Kleemann, G, and C Murphy. 2009. “The Endocrine Regulation of Aging in Caenorhabditis Elegans.”. Mol Cell Endocrinol 299 (1): 51-7. doi:10.1016/j.mce.2008.10.048.
Chikina, Maria, Curtis Huttenhower, Coleen Murphy, and Olga Troyanskaya. (2009) 2009. “Global Prediction of Tissue-Specific Gene Expression and Context-Dependent Gene Networks in Caenorhabditis Elegans.”. PLoS Comput Biol 5 (6): e1000417. doi:10.1371/journal.pcbi.1000417.
Oliveira, Riva, Jess Abate, Kieran Dilks, Jessica Landis, Jasmine Ashraf, Coleen Murphy, and Keith Blackwell. 2009. “Condition-Adapted Stress and Longevity Gene Regulation by Caenorhabditis Elegans SKN-1 Nrf.”. Aging Cell 8 (5): 524-41. doi:10.1111/j.1474-9726.2009.00501.x.
Lee, Seung-Jae, Coleen Murphy, and Cynthia Kenyon. (2009) 2009. “Glucose Shortens the Life Span of C. Elegans by Downregulating DAF-16 FOXO Activity and Aquaporin Gene Expression.”. Cell Metab 10 (5): 379-91. doi:10.1016/j.cmet.2009.10.003.
Luo, Shijing, Wendy Shaw, Jasmine Ashraf, and Coleen Murphy. (2009) 2009. “TGF-Beta Sma Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging.”. PLoS Genet 5 (12): e1000789. doi:10.1371/journal.pgen.1000789.

2010

Landis, Jessica, and Coleen Murphy. (2010) 2010. “Integration of Diverse Inputs in the Regulation of Caenorhabditis Elegans DAF-16 FOXO.”. Dev Dyn 239 (5): 1405-12. doi:10.1002/dvdy.22244.
Kauffman, Amanda, Jasmine Ashraf, Ryan Corces-Zimmerman, Jessica Landis, and Coleen Murphy. 2010. “Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory With Age.”. PLoS Biol 8 (5): e1000372. doi:10.1371/journal.pbio.1000372.
Kaletsky, Rachel, and Coleen Murphy. (2010) 2010. “The Role of Insulin IGF-Like Signaling in C. Elegans Longevity and Aging.”. Dis Model Mech 3 (7-8): 415-9. doi:10.1242/dmm.001040.
Luo, Shijing, Gunnar Kleemann, Jasmine Ashraf, Wendy Shaw, and Coleen Murphy. 2010. “TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance.”. Cell 143 (2): 299-312. doi:10.1016/j.cell.2010.09.013.
Murphy, Coleen. 2010. “Aging: MiRacles of Longevity?”. Curr Biol 20 (24). doi:10.1016/j.cub.2010.11.018.

2011

Rizki, Gizem, Terri Iwata, Ji Li, Christian Riedel, Colette Picard, Max Jan, Coleen Murphy, and Siu Lee. (2011) 2011. “The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1 SIRT1 Collaborate to Regulate DAF-16 FOXO.”. PLoS Genet 7 (9): e1002235. doi:10.1371/journal.pgen.1002235.
Liu, Gang, Jason Rogers, Coleen Murphy, and Christopher Rongo. 2011. “EGF Signalling Activates the Ubiquitin Proteasome System to Modulate C. Elegans Lifespan.”. EMBO J 30 (15): 2990-3003. doi:10.1038/emboj.2011.195.