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Found 38 results
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Journal Article
Murphy CT, Lee S-J, Kenyon C.  2007.  Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.. Proc Natl Acad Sci U S A. 104(48):19046-50.
Luo S, Kleemann GA, Ashraf JM, Shaw WM, Murphy CT.  2010.  TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance.. Cell. 143(2):299-312.
Luo S, Shaw WM, Ashraf J, Murphy CT.  2009.  TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging.. PLoS Genet. 5(12):e1000789.
Murphy CT.  2006.  The search for DAF-16/FOXO transcriptional targets: approaches and discoveries.. Exp Gerontol. 41(10):910-21.
Kaletsky R, Murphy CT.  2010.  The role of insulin/IGF-like signaling in C. elegans longevity and aging.. Dis Model Mech. 3(7-8):415-9.
Hsu A-L, Murphy CT, Kenyon C.  2003.  Regulation of aging and age-related disease by DAF-16 and heat-shock factor.. Science. 300(5622):1142-5.
Tepper RG, Ashraf J, Kaletsky R, Kleemann G, Murphy CT, Bussemaker HJ.  2013.  PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity.. Cell. 154(3):676-690.
Li L-B, Lei H, Arey RN, Li P, Liu J, Murphy CT, Xu XZShawn, Shen K.  2016.  The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory.. Curr Biol. 26(5):605-15.
Li S, Stone HA, Murphy CT.  2015.  A microfluidic device and automatic counting system for the study of C. elegans reproductive aging.. Lab Chip. 15(2):524-31.
Shi C, Murphy CT.  2014.  Mating induces shrinking and death in Caenorhabditis mothers.. Science. 343(6170):536-40.
Landis JN, Murphy CT.  2010.  Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.. Dev Dyn. 239(5):1405-12.
de Abreu DAndrea Fer, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, López-Moyado IF, Vaggi F et al..  2014.  An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.. PLoS Genet. 10(3):e1004225.
Murphy CT, Hu PJ.  2013.  Insulin/insulin-like growth factor signaling in C. elegans.. WormBook. :1-43.
Kauffman AL, Ashraf JM, M Corces-Zimmerman R, Landis JN, Murphy CT.  2010.  Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.. PLoS Biol. 8(5):e1000372.
Lee S-J, Murphy CT, Kenyon C.  2009.  Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.. Cell Metab. 10(5):379-91.
Chikina MD, Huttenhower C, Murphy CT, Troyanskaya OG.  2009.  Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans.. PLoS Comput Biol. 5(6):e1000417.
Lakhina V, Arey RN, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, Murphy CT.  2015.  Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs.. Neuron. 85(2):330-45.
Lakhina V, Murphy CT.  2015.  Genome Sequencing Fishes out Longevity Genes.. Cell. 163(6):1312-3.
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C.  2003.  Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.. Nature. 424(6946):277-83.
Lakhina V, Murphy CT.  2015.  For longevity, perception is everything.. Cell. 160(5):807-809.
Shi C, Murphy CT.  2016.  Feeding the germline.. Genes Dev. 30(3):249-50.
Rizki G, Iwata TNaoko, Li J, Riedel CG, Picard CLafontaine, Jan M, Murphy CT, Lee SSylvia.  2011.  The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.. PLoS Genet. 7(9):e1002235.
Kenyon C, Murphy CT.  2006.  Enrichment of regulatory motifs upstream of predicted DAF-16 targets.. Nat Genet. 38(4):397-8;authorreply398.
Liu G, Rogers J, Murphy CT, Rongo C.  2011.  EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan.. EMBO J. 30(15):2990-3003.
Ewald CY, Landis JN, Abate JPorter, Murphy CT, T Blackwell K.  2015.  Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.. Nature. 519(7541):97-101.

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