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Signal Transduction
Li L-B, Lei H, Arey RN, Li P, Liu J, Murphy CT, Xu XZShawn, Shen K.  2016.  The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory.. Curr Biol. 26(5):605-15.
Liu G, Rogers J, Murphy CT, Rongo C.  2011.  EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan.. EMBO J. 30(15):2990-3003.
Murphy CT, Hu PJ.  2013.  Insulin/insulin-like growth factor signaling in C. elegans.. WormBook. :1-43.
Tepper RG, Murphy CT, Bussemaker HJ.  2014.  DAF-16 and PQM-1: partners in longevity.. Aging (Albany NY). 6(1):5-6.
de Abreu DAndrea Fer, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, López-Moyado IF, Vaggi F et al..  2014.  An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.. PLoS Genet. 10(3):e1004225.
Lakhina V, Murphy CT.  2015.  For longevity, perception is everything.. Cell. 160(5):807-809.
DiLoreto R, Murphy CT.  2015.  The cell biology of aging.. Mol Biol Cell. 26(25):4524-31.
Hahm J-H, Kim S, DiLoreto R, Shi C, Lee S-JV, Murphy CT, Nam HGil.  2015.  C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation.. Nat Commun. 6:8919.
Ewald CY, Landis JN, Abate JPorter, Murphy CT, T Blackwell K.  2015.  Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.. Nature. 519(7541):97-101.
Kaletsky R, Lakhina V, Arey R, Williams A, Landis J, Ashraf J, Murphy CT.  2016.  The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.. Nature. 529(7584):92-6.
Shi C, Murphy CT.  2016.  Feeding the germline.. Genes Dev. 30(3):249-50.
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C.  2003.  Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.. Nature. 424(6946):277-83.
Murphy CT.  2006.  The search for DAF-16/FOXO transcriptional targets: approaches and discoveries.. Exp Gerontol. 41(10):910-21.
Shaw WM, Luo S, Landis J, Ashraf J, Murphy CT.  2007.  The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.. Curr Biol. 17(19):1635-45.
Rizki G, Iwata TNaoko, Li J, Riedel CG, Picard CLafontaine, Jan M, Murphy CT, Lee SSylvia.  2011.  The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.. PLoS Genet. 7(9):e1002235.
Luo S, Murphy CT.  2011.  Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms.. Genesis. 49(2):53-65.
Kauffman AL, Ashraf JM, M Corces-Zimmerman R, Landis JN, Murphy CT.  2010.  Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.. PLoS Biol. 8(5):e1000372.
Kaletsky R, Murphy CT.  2010.  The role of insulin/IGF-like signaling in C. elegans longevity and aging.. Dis Model Mech. 3(7-8):415-9.
Landis JN, Murphy CT.  2010.  Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.. Dev Dyn. 239(5):1405-12.
Luo S, Kleemann GA, Ashraf JM, Shaw WM, Murphy CT.  2010.  TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance.. Cell. 143(2):299-312.
Luo S, Shaw WM, Ashraf J, Murphy CT.  2009.  TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging.. PLoS Genet. 5(12):e1000789.
Lee S-J, Murphy CT, Kenyon C.  2009.  Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.. Cell Metab. 10(5):379-91.
Murphy CT, Lee S-J, Kenyon C.  2007.  Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.. Proc Natl Acad Sci U S A. 104(48):19046-50.