Publications Search

Found 25 results
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2019
Shi C, Booth LN, Murphy CT.  2019.  Insulin-like peptides and the mTOR-TFEB pathway protect \textitCaenorhabditis elegans hermaphrodites from mating-induced death. eLife. 8:e46413.
2016
Kaletsky R, Lakhina V, Arey R, Williams A, Landis J, Ashraf J, Murphy CT.  2016.  The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.. Nature. 529(7584):92-6.
2015
Hahm J-H, Kim S, DiLoreto R, Shi C, Lee S-JV, Murphy CT, Nam HGil.  2015.  C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation.. Nat Commun. 6:8919.
DiLoreto R, Murphy CT.  2015.  The cell biology of aging.. Mol Biol Cell. 26(25):4524-31.
Ewald CY, Landis JN, Abate JPorter, Murphy CT, T Blackwell K.  2015.  Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.. Nature. 519(7541):97-101.
Ewald CY, Landis JN, Abate JPorter, Murphy CT, T Blackwell K.  2015.  Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.. Nature. 519(7541):97-101.
Lakhina V, Arey RN, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, Murphy CT.  2015.  Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs.. Neuron. 85(2):330-45.
Li S, Stone HA, Murphy CT.  2015.  A microfluidic device and automatic counting system for the study of C. elegans reproductive aging.. Lab Chip. 15(2):524-31.
2014
Tepper RG, Murphy CT, Bussemaker HJ.  2014.  DAF-16 and PQM-1: partners in longevity.. Aging (Albany NY). 6(1):5-6.
de Abreu DAndrea Fer, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, López-Moyado IF, Vaggi F et al..  2014.  An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology.. PLoS Genet. 10(3):e1004225.
Shi C, Murphy CT.  2014.  Mating induces shrinking and death in Caenorhabditis mothers.. Science. 343(6170):536-40.
2013
Tepper RG, Ashraf J, Kaletsky R, Kleemann G, Murphy CT, Bussemaker HJ.  2013.  PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity.. Cell. 154(3):676-690.
2011
Rizki G, Iwata TNaoko, Li J, Riedel CG, Picard CLafontaine, Jan M, Murphy CT, Lee SSylvia.  2011.  The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.. PLoS Genet. 7(9):e1002235.
2010
Murphy CT.  2010.  Aging: miRacles of longevity? Curr Biol. 20(24):R1076-8.
Kauffman AL, Ashraf JM, M Corces-Zimmerman R, Landis JN, Murphy CT.  2010.  Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.. PLoS Biol. 8(5):e1000372.
Kaletsky R, Murphy CT.  2010.  The role of insulin/IGF-like signaling in C. elegans longevity and aging.. Dis Model Mech. 3(7-8):415-9.
2009
Oliveira RP, Abate JPorter, Dilks K, Landis J, Ashraf J, Murphy CT, T Blackwell K.  2009.  Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.. Aging Cell. 8(5):524-41.
Lee S-J, Murphy CT, Kenyon C.  2009.  Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.. Cell Metab. 10(5):379-91.
Luo S, Shaw WM, Ashraf J, Murphy CT.  2009.  TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging.. PLoS Genet. 5(12):e1000789.
2007
Shaw WM, Luo S, Landis J, Ashraf J, Murphy CT.  2007.  The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.. Curr Biol. 17(19):1635-45.
Murphy CT, Lee S-J, Kenyon C.  2007.  Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.. Proc Natl Acad Sci U S A. 104(48):19046-50.
Murphy CT, Lee S-J, Kenyon C.  2007.  Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.. Proc Natl Acad Sci U S A. 104(48):19046-50.
2006
Murphy CT.  2006.  The search for DAF-16/FOXO transcriptional targets: approaches and discoveries.. Exp Gerontol. 41(10):910-21.
2003
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C.  2003.  Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.. Nature. 424(6946):277-83.
Hsu A-L, Murphy CT, Kenyon C.  2003.  Regulation of aging and age-related disease by DAF-16 and heat-shock factor.. Science. 300(5622):1142-5.