Publications Search

95 Publications


Kaletsky R, Murphy C. 2010. The role of insulin/IGF-like signaling in C. elegans longevity and aging. Dis Model Mech. 3(7-8):415-9. doi:10.1242/dmm.001040.
Kaletsky R, Murphy C. 2019. Gut feelings: microRNAs tune protein quality control and ageing to odours. 1(3): - 307.
Kaletsky R, Moore R, Parsons L, Murphy C. 2019. Cross-kingdom recognition of bacterial small RNAs induces transgenerational pathogenic avoidance. bioRxiv. 697888 .
Kaletsky R, Yao V, Williams A, Runnels A, Tadych A, Zhou S, Troyanskaya O, Murphy C. 2018. Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression. PLoS Genet. 14(8):e1007559. doi:10.1371/journal.pgen.1007559.
Kauffman A, Ashraf J, Corces-Zimmerman R, Landis J, Murphy C. 2010. Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biol. 8(5):e1000372. doi:10.1371/journal.pbio.1000372.
Kauffman A, Parsons L, Stein G, Wills A, Kaletsky R, Murphy C. 2011. C. elegans positive butanone learning, short-term, and long-term associative memory assays. J Vis Exp.(49). doi:10.3791/2490.
Kenyon C, Murphy C. 2006. Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nat Genet. 38(4):397-8; author reply 398. doi:10.1038/ng0406-397.
Kleemann G, Murphy C. 2009. The endocrine regulation of aging in Caenorhabditis elegans. Mol Cell Endocrinol. 299(1):51-7. doi:10.1016/j.mce.2008.10.048.


Lakhina V, Arey R, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, Murphy C. 2015. Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs. Neuron. 85(2):330-45. doi:10.1016/j.neuron.2014.12.029.
Lakhina V, Murphy C. 2015. For longevity, perception is everything. Cell. 160(5):807-809. doi:10.1016/j.cell.2015.02.027.
Lakhina V, Murphy C. 2015. Genome Sequencing Fishes out Longevity Genes. Cell. 163(6):1312-3. doi:10.1016/j.cell.2015.11.040.
Lakhina V, McReynolds M, Grimes D, Rabinowitz J, Burdine R, Murphy C. 2019. ZIP-5/bZIP transcription factor regulation of folate metabolism is critical for aging axon regeneration. bioRxiv.:727719.
Landis J, Murphy C. 2010. Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev Dyn. 239(5):1405-12. doi:10.1002/dvdy.22244.
Lee S-J, Murphy C, Kenyon C. 2009. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10(5):379-91. doi:10.1016/j.cmet.2009.10.003.
Lee Y, Jung Y, Jeong DE, Hwang W, Ham S, Park HH, Kwon S, Ashraf JM, Murphy CT, Lee SV. 2021. 9. Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop.
Li S, Stone H, Murphy C. 2015. A microfluidic device and automatic counting system for the study of C. elegans reproductive aging. Lab Chip. 15(2):524-31. doi:10.1039/c4lc01028k.
Li L-B, Lei H, Arey R, Li P, Liu J, Murphy C, Xu X, Shen K. 2016. The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory. Curr Biol. 26(5):605-15. doi:10.1016/j.cub.2015.12.068.
Liu G, Rogers J, Murphy C, Rongo C. 2011. EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. EMBO J. 30(15):2990-3003. doi:10.1038/emboj.2011.195.
Luo S, Shaw W, Ashraf J, Murphy C. 2009. TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. PLoS Genet. 5(12):e1000789. doi:10.1371/journal.pgen.1000789.
Luo S, Kleemann G, Ashraf J, Shaw W, Murphy C. 2010. TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. Cell. 143(2):299-312. doi:10.1016/j.cell.2010.09.013.
Luo S, Murphy C. 2011. Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms. Genesis. 49(2):53-65. doi:10.1002/dvg.20694.


Mack HID, Heimbucher T, Murphy CT. 2019. The nematode Caenorhabditis elegans as a model for aging research. Drug Discov Today: Disease Models .
Maliha G, Murphy C. 2016. A simple offspring-to-mother size ratio predicts post-reproductive lifespan. bioRxiv.. doi:10.1101/048835.
McCarroll S, Murphy C, Zou S, Pletcher S, Chin C-S, Jan Y, Kenyon C, Bargmann C, Li H. 2004. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet. 36(2):197-204. doi:10.1038/ng1291.
Moore RS, Kaletsky R, Lesnik C, Cota V, Blackman E, Parsons LR, Gitai Z, Murphy CT. 2020. 1. “Horizontal and vertical transmission of transgenerational memories via the Cer1 transposon. bioRxiv. .