Publications Search

95 Publications


Shi C, Murphy C. 2016. Feeding the germline. Genes Dev. 30(3):249-50. doi:10.1101/gad.276980.115.
Lakhina V, Murphy C. 2015. For longevity, perception is everything. Cell. 160(5):807-809. doi:10.1016/j.cell.2015.02.027.


Murphy C, McCarroll S, Bargmann C, Fraser A, Kamath R, Ahringer J, Li H, Kenyon C. 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 424(6946):277-83. doi:10.1038/nature01789.
Lakhina V, Murphy C. 2015. Genome Sequencing Fishes out Longevity Genes. Cell. 163(6):1312-3. doi:10.1016/j.cell.2015.11.040.
Lakhina V, Arey R, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, Murphy C. 2015. Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs. Neuron. 85(2):330-45. doi:10.1016/j.neuron.2014.12.029.
Chikina M, Huttenhower C, Murphy C, Troyanskaya O. 2009. Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans. PLoS Comput Biol. 5(6):e1000417. doi:10.1371/journal.pcbi.1000417.
Lee S-J, Murphy C, Kenyon C. 2009. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10(5):379-91. doi:10.1016/j.cmet.2009.10.003.
Kaletsky R, Murphy C. 2019. Gut feelings: microRNAs tune protein quality control and ageing to odours. 1(3): - 307.


Kauffman A, Ashraf J, Corces-Zimmerman R, Landis J, Murphy C. 2010. Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biol. 8(5):e1000372. doi:10.1371/journal.pbio.1000372.
Templeman N, Luo S, Kaletsky R, Shi C, Ashraf J, Keyes W, Murphy C. 2018. Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. Curr Biol. 28(5):753-760.e4. doi:10.1016/j.cub.2018.01.052.
Shi C, Booth L, Murphy C, Kaeberlein M, Wittkopp P, Sutphin G. 2019. Insulin-like peptides and the mTOR-TFEB pathway protect \textitCaenorhabditis elegans hermaphrodites from mating-induced death. eLife. 8:e46413. doi:10.7554/eLife.46413.
de Abreu D, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes W, Nash Z, López-Moyado I, Vaggi F, et al. 2014. An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genet. 10(3):e1004225. doi:10.1371/journal.pgen.1004225.
Murphy C, Hu P. 2013. Insulin/insulin-like growth factor signaling in C. elegans. WormBook.:1-43. doi:10.1895/wormbook.1.164.1.
Landis J, Murphy C. 2010. Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev Dyn. 239(5):1405-12. doi:10.1002/dvdy.22244.
Yao V, Kaletsky R, Keyes W, Mor D, Wong A, Sohrabi S, Murphy C, Troyanskaya O. 2018. An integrative tissue-network approach to identify and test human disease genes. Nat Biotechnol.. doi:10.1038/nbt.4246.
Stein G, Murphy C. 2012. The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans. Front Genet. 3:259. doi:10.3389/fgene.2012.00259.
Heimbucher T, Murphy C. 2019. Investigating Mechanisms that Control Ubiquitin-Mediated DAF-16/FOXO Protein Turnover. Methods Mol Biol. 1890:41-49. doi:10.1007/978-1-4939-8900-3_4.


Shi C, Runnels A, Murphy C, Dillin A. 2017. Mating and male pheromone kill \textitCaenorhabditis males through distinct mechanisms. eLife. 6:e23493. doi:10.7554/eLife.23493.
Shi C, Murphy C. 2014. Mating induces shrinking and death in Caenorhabditis mothers. Science. 343(6170):536-40. doi:10.1126/science.1242958.
Shi C, Runnels A, Murphy C. 2016. Mating-induced Male Death and Pheromone Toxin-regulated Androstasis. bioRxiv.. doi:10.1101/034181.
Li S, Stone H, Murphy C. 2015. A microfluidic device and automatic counting system for the study of C. elegans reproductive aging. Lab Chip. 15(2):524-31. doi:10.1039/c4lc01028k.
Murphy C, Rock R, Spudich J. 2001. A myosin II mutation uncouples ATPase activity from motility and shortens step size. Nat Cell Biol. 3(3):311-5. doi:10.1038/35060110.


Mack HID, Heimbucher T, Murphy CT. 2019. The nematode Caenorhabditis elegans as a model for aging research. Drug Discov Today: Disease Models .
Arey RN, Kaletsky R, Murphy CT. 2019. Nervous system-wide profiling of presynaptic mRNAs reveals regulators of associative memory. Sci Rep, . 9.
Li L-B, Lei H, Arey R, Li P, Liu J, Murphy C, Xu X, Shen K. 2016. The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory. Curr Biol. 26(5):605-15. doi:10.1016/j.cub.2015.12.068.