Publications Search

95 Publications


Caudy A, Guan Y, Jia Y, Hansen C, DeSevo C, Hayes A, Agee J, Alvarez-Dominguez J, Arellano H, Barrett D, Bauerle C, Bisaria N, Bradley P, Breunig S, Bush E, Cappel D, Capra E, Chen W, Clore J, Combs P, Doucette C, Demuren O, Fellowes P, Freeman S, Frenkel E, Gadala-Maria D, Gawande R, Glass D, Grossberg S, Gupta A, Hammonds-Odie L, Hoisos A, Hsi J, Hsu Y-H, Inukai S, Karczewski K, Ke X, Kojima M, Leachman S, Lieber D, Liebowitz A, Liu J, Liu Y, Martin T, Mena J, Mendoza R, Myhrvold C, Millian C, Pfau S, Raj S, Rich M, Rokicki J, Rounds W, Salazar M, Salesi M, Sharma R, Silverman S, Singer C, Sinha S, Staller M, Stern P, Tang H, Weeks S, Weidmann M, Wolf A, Young C, Yuan J, Crutchfield C, McClean M, Murphy C, Llinás M, Botstein D, Troyanskaya O, Dunham M. 2013. A new system for comparative functional genomics of Saccharomyces yeasts. Genetics. 195(1):275–87. doi:10.1534/genetics.113.152918.


Heimbucher T, Murphy C. 2019. A PBX/MEIS Complex Balances Reproduction and Somatic Resilience. Developmental Cell. 49(2).
Moore R, Kaletsky R, Murphy C. 2019. Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance. Cell. 177(7): - 1841.e12.
Tepper R, Ashraf J, Kaletsky R, Kleemann G, Murphy C, Bussemaker H. 2013. PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell. 154(3):676–690. doi:10.1016/j.cell.2013.07.006.
Heimbucher T, Hog J, Murphy C. 2019. PQM-1 controls hypoxic survival via regulation of lipid metabolism. bioRxiv.
Arey R, Kaletsky R, Murphy C. 2019. Profiling of presynaptic mRNAs reveals a role for axonal PUMILIOs in associative memory formation. bioRxiv. doi:10.1101/733428.


Hsu A-L, Murphy C, Kenyon C. 2003. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 300(5622):1142–5. doi:10.1126/science.1083701.
Templeman N, Murphy C. 2018. Regulation of reproduction and longevity by nutrient-sensing pathways. The Journal of Cell Biology. 217:93–106. doi:10.1083/jcb.201707168.
Son H, Seo M, Ham S, Hwang W, Lee D, An S, Artan M, Seo K, Kaletsky R, Arey R, Ryu Y, Ha C, Kim Y, Murphy C, Roh T-Y, Nam H, Lee S-J. 2017. RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans. Nat Commun. 8:14749. doi:10.1038/ncomms14749.
Kaletsky R, Murphy C. 2010. The role of insulin/IGF-like signaling in C. elegans longevity and aging. Dis Model Mech. 3(7-8):415–9. doi:10.1242/dmm.001040.


Murphy C. 2006. The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. Exp Gerontol. 41(10):910–21. doi:10.1016/j.exger.2006.06.040.
Murphy C, Spudich J. 1999. The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity. Biochemistry. 38(12):3785–92. doi:10.1021/bi9826815.
Maliha G, Murphy C. 2016. A simple offspring-to-mother size ratio predicts post-reproductive lifespan. bioRxiv. doi:10.1101/048835.


Luo S, Shaw W, Ashraf J, Murphy C. 2009. TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. PLoS Genet. 5(12):e1000789. doi:10.1371/journal.pgen.1000789.
Luo S, Kleemann G, Ashraf J, Shaw W, Murphy C. 2010. TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance. Cell. 143(2):299–312. doi:10.1016/j.cell.2010.09.013.
Murphy C, Lee S-J, Kenyon C. 2007. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A. 104(48):19046–50. doi:10.1073/pnas.0709613104.
Kaletsky R, Yao V, Williams A, Runnels A, Tadych A, Zhou S, Troyanskaya O, Murphy C. 2018. Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression. PLoS Genet. 14(8):e1007559. doi:10.1371/journal.pgen.1007559.


Murphy C. 2006. Using whole-genome transcriptional analyses to identify molecular mechanisms of aging. Drug Discovery Today: Disease Mechanisms. 3:41–46. doi:


Murphy C, Spudich J. 2000. Variable surface loops and myosin activity: accessories to a motor. J Muscle Res Cell Motil. 21(2):139–51.


Lakhina V, McReynolds M, Grimes D, Rabinowitz J, Burdine R, Murphy C. 2019. ZIP-5/bZIP transcription factor regulation of folate metabolism is critical for aging axon regeneration. bioRxiv.:727719.