Using whole-genome transcriptional analyses to identify molecular mechanisms of aging

TitleUsing whole-genome transcriptional analyses to identify molecular mechanisms of aging
Publication TypeJournal Article
Year of Publication2006
AuthorsMurphy CT
JournalDrug Discovery Today: Disease Mechanisms
Volume3
Pagination41 - 46
ISSN1740-6765
Abstract

Whole-genome transcriptional analyses of aging organisms and tissues have revealed changes in many genes and biological processes. A comparison of these studies reveals common age-related changes, including the downregulation of metabolic and mitochondrial function, and the upregulation of stress and immune responses. This suggests that much of the aging process might be conserved across species, although tissue- and species-specific changes also occur. These comparisons will help identify the underlying mechanisms of aging.

URLhttp://www.sciencedirect.com/science/article/pii/S1740676506000125
DOI10.1016/j.ddmec.2006.02.012
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