Variable surface loops and myosin activity: accessories to a motor.

TitleVariable surface loops and myosin activity: accessories to a motor.
Publication TypeJournal Article
Year of Publication2000
AuthorsMurphy CT, Spudich JA
JournalJ Muscle Res Cell Motil
Volume21
Issue2
Pagination139-51
Date Published2000 Feb
ISSN0142-4319
KeywordsActins, Amino Acid Sequence, Animals, Humans, Muscle, Skeletal, Muscle, Smooth, Myosins
Abstract

The catalytic head of myosin is a globular structure that has historically been divided into three segments of 25, 50, and 20 kDa. The solvent-exposed, proteolytically-sensitive surface loops of myosin that join these three segments are highly variable in their sequences. While surface loops have not traditionally been thought to affect enzymatic activities, these loops lie near the ATP and actin-binding sites and have been implicated in the modulation of myosin's kinetic activities. In this work we review the wealth of data regarding the loops that has accumulated over the years and discuss the roles of the loops in contributing to the different activities displayed by different myosin isoforms.

Alternate JournalJ. Muscle Res. Cell. Motil.
PubMed ID10961838
Grant List33289 / / PHS HHS / United States