Title | Variable surface loops and myosin activity: accessories to a motor. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Murphy CT, Spudich JA |
Journal | J Muscle Res Cell Motil |
Volume | 21 |
Issue | 2 |
Pagination | 139-51 |
Date Published | 2000 Feb |
ISSN | 0142-4319 |
Keywords | Actins, Amino Acid Sequence, Animals, Humans, Muscle, Skeletal, Muscle, Smooth, Myosins |
Abstract | The catalytic head of myosin is a globular structure that has historically been divided into three segments of 25, 50, and 20 kDa. The solvent-exposed, proteolytically-sensitive surface loops of myosin that join these three segments are highly variable in their sequences. While surface loops have not traditionally been thought to affect enzymatic activities, these loops lie near the ATP and actin-binding sites and have been implicated in the modulation of myosin's kinetic activities. In this work we review the wealth of data regarding the loops that has accumulated over the years and discuss the roles of the loops in contributing to the different activities displayed by different myosin isoforms. |
Alternate Journal | J. Muscle Res. Cell. Motil. |
Full Text | |
PubMed ID | 10961838 |
Grant List | 33289 / / PHS HHS / United States |